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    Separation, synthesis, and cytotoxicity of a series of mogrol derivatives

     

    论文题目

    Separation, synthesis, and cytotoxicity of a series of mogrol derivatives

       

    Lei Wang, Lianchun Li, Yuxia Fu

    发表期刊

    Journal of Asian Natural Products Research

    //

    2019

       

         Four metabolites of mogrol were separated, identified and characterized. Their antitumor activity was evaluated, and the results showed side chain modification would probably enhance the cytotoxicity. Therefore, three types of amines, alcohols and rigid planar derivatives were synthesized. Compounds 20 and 21 containing a tetrahydro-b-carboline structure at the end of the side chain exhibited IC50 values around 2–9 lM against A549 and CNE1 cell comparing with 80–90 lM of mogrol. Structure analysis suggested that the perhydrocyclopentanophenanthrene moiety and the tetrahydro-b-carboline moiety could probably enhance the activity through an intramolecular synergistic effect.


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